abstract：:Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability. In this study, a human ...

journal_title：Pain

authors： Rabert DK,Koch BD,Ilnicka M,Obernolte RA,Naylor SL,Herman RC,Eglen RM,Hunter JC,Sangameswaran L

更新日期：1998-11-01 00:00:00

abstract：:Inflammation enhances release of neuropeptides from sensory nerve terminals in the spinal cord, and this may contribute to the development of hyperalgesia. In a similar manner, proinflammatory prostaglandins also augment peptide release from sensory neurons. To ascertain whether the inflammation-induced increase in pe...

journal_title：Pain

authors： Southall DM,Michael LR,Vasko RM

更新日期：1998-10-01 00:00:00

abstract：:The present study examined the role of catastrophizing in predicting levels of pain and disability in a sample of individuals who had sustained soft-tissue injuries to the neck, shoulders or back following work or motor vehicle accidents. Participants were 86 (27 men, 59 women) consecutive referrals to the Atlantic Pa...

journal_title：Pain

authors： Sullivan MJL,Stanish W,Waite H,Sullivan M,Tripp DA

更新日期：1998-09-01 00:00:00

abstract：:A secondary zone of cutaneous hyperalgesia in humans is characterized by increased pain to mechanical stimuli. In contrast, the perception of heat stimuli delivered to a secondary zone of hyperalgesia in humans often shows a paradoxical decrease in magnitude. A number of studies have shown that the responses of spinal...

journal_title：Pain

authors： Dougherty MP,Willis DW,Lenz AF

更新日期：1998-08-01 00:00:00

abstract：:Women with chronic pelvic pain experience serious distress and lifestyle disruption. Confronted with a difficult condition to diagnose and treat effectively, doctors express a negative perception of this group of 'heartsink' patients. This study aimed to characterise medical attitudes towards the treatment of women wi...

journal_title：Pain

authors： Selfe SA,Van Vugt M,Stones WR

更新日期：1998-08-01 00:00:00

abstract：:A 1-year follow-up of two preadolescent age cohorts with musculoskeletal pain at least once a week was conducted to analyze predictive factors for the persistence of musculoskeletal pain. Of the 564 children with pain at baseline, representing one third of the sample studied, 515 (91.3%) could be followed and 452 (80....

journal_title：Pain

authors： Mikkelsson M,Salminen JJ,Sourander A,Kautiainen H

更新日期：1998-07-01 00:00:00

abstract：:In a double-blind, cross-over study, ibuprofen (600 mg), a peripherally-acting selective kappa-opioid receptor agonist (7.5 mg), or placebo were given orally in experiments on healthy volunteers 1 h before assessment of pain thresholds to radiant heat and of pain ratings to controlled mechanical impact stimuli. Mechan...

journal_title：Pain

authors： Bickel A,Dorfs S,Schmelz M,Forster C,Uhl W,Handwerker OH

更新日期：1998-06-01 00:00:00

abstract：:We report a case control study comparing patients attending a pain clinic whose symptoms were not considered medically explained (cases) with those whose symptoms were considered medically explained (controls). Principal comparisons were psychiatric morbidity, medication use, and iatrogenic factors assessed by intervi...

journal_title：Pain

authors： Kouyanou K,Pither CE,Rabe-Hesketh S,Wessely S

更新日期：1998-06-01 00:00:00

abstract：:Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. Several studies have reported that TMD is associated with enhanced sensitivity to experimental pain. Twenty-three TMD subjects and 24 pain-free matched control subject...

journal_title：Pain

authors： Maixner W,Fillingim R,Sigurdsson A,Kincaid S,Silva S

更新日期：1998-05-01 00:00:00

abstract：:Surgery and trauma are recognised as important causes of chronic pain, although their overall contribution has not been systematically studied. This paper reports on the contribution of surgery and trauma to chronic pain among 5130 patients attending 10 outpatient clinics located throughout North Britain. Surgery cont...

journal_title：Pain

authors： Crombie IK,Davies HT,Macrae WA

更新日期：1998-05-01 00:00:00

abstract：:The purpose of this study was to examine the utility of the pain map as a pain assessment tool in frail nursing home residents. The study was conducted in two phases. In Phase 1, nursing home staff's knowledge of the locations of resident pain complaints was examined. We found significant deficiencies in this knowledg...

journal_title：Pain

authors： Weiner D,Peterson B,Keefe F

更新日期：1998-05-01 00:00:00

abstract：:Two classes of neurons with distinct responses to opioids have been identified in the rostral ventromedial medulla (RVM), a region with a well-documented role in nociceptive modulation. 'On-cells' are directly inhibited by opioids, and opioids can thus gain access to the modulatory circuitry of the RVM by an action on...

journal_title：Pain

authors： Heinricher MM,McGaraughty S

更新日期：1998-04-01 00:00:00

abstract：:Recent studies into the common complaint of chronic neck pain have focused on its anatomical origin, identifying especially the cervical zygapophysial joints. However the pathophysiology of chronic neck pain remains poorly understood. In this psychophysical study, responses to electrocutaneous stimulation in subjects ...

journal_title：Pain

authors： Sheather-Reid RB,Cohen ML

更新日期：1998-04-01 00:00:00

abstract：:The aim of the present study was to determine if acupuncture stimulation inhibits sympathetic nerve activity in humans. Multiunit efferent postganglionic sympathetic activity was recorded with a tungsten microelectrode inserted in a muscle fascicle of the peroneal nerve. Mean arterial pressure, heart rate and skin blo...

journal_title：Pain

authors： Knardahl S,Elam M,Olausson B,Wallin GB

更新日期：1998-03-01 00:00:00

abstract：:Central antinociceptive effects of cannabinoids have been well documented. However, relatively little is known about the peripheral effects of the cannabinoids on inflammation. In the present study, we evaluated the effects of peripherally administered cannabinoids on three indices of inflammation: carrageenan-induced...

journal_title：Pain

authors： Richardson JD,Kilo S,Hargreaves KM

更新日期：1998-03-01 00:00:00

abstract：:The ascending Method of Limits, used for the determination of pressure pain thresholds (PPT), is not a psychophysically robust method. The present study sought to determine if the examiner's expectancy, based on whether the measurement site was clinically 'painful' or 'non-painful', would bias the obtained PPT values....

journal_title：Pain

authors： Ohrbach R,Crow H,Kamer A

更新日期：1998-02-01 00:00:00

abstract：:Wind-up and secondary hyperalgesia both are related to central sensitization, but whereas the former is explained by homosynaptic facilitation, the latter is due to heterosynaptic facilitation. To investigate possible interactions between both types of facilitation, we tested for alterations of perceptual wind-up in t...

journal_title：Pain

authors： Magerl W,Wilk SH,Treede RD

更新日期：1998-02-01 00:00:00

abstract：:Gabapentin is an effective option for the treatment of neuropathic pain syndromes because of its efficacy and favorable side-effect profile. A case is presented of a 58 year old man who developed a painful polyneuropathy while being treated with gabapentin. ...

journal_title：Pain

authors： Gould HJ

更新日期：1998-02-01 00:00:00

abstract：:Effect of weight bearing of the hindlimbs on the assessment of mechanically-induced hindlimb withdrawal threshold was determined in intact rats and in rats with various pathophysiological conditions causing allodynia or hyperalgesia. Hindlimb withdrawal was elicited by applying a series of calibrated monofilaments to ...

journal_title：Pain

authors： Kauppila T,Kontinen VK,Pertovaara A

更新日期：1998-01-01 00:00:00

abstract：:The purpose of this study was to investigate the mechanisms of referred pain observed in female patients with pain from the reproductive organs. We developed a model of inflammatory uterine pain in the rat. Inflammation of the uterus in rats pretreated with Evans Blue Dye resulted in dye extravasation in the skin over...

journal_title：Pain

authors： Wesselmann U,Lai J

更新日期：1997-12-01 00:00:00

abstract：:This paper presents the results of a detailed study of the pain epidemiology and health related quality of life (HRQL) in 150 chronic non-malignant pain patients consecutively referred to a Danish multidisciplinary pain center. Mean pain severity was 71.6 (SD = 18.5) on the VAS scale. Forty-two percent reported poor q...

journal_title：Pain

authors： Becker N,Thomsen AB,Olsen AK,Sjøgren P,Bech P,Eriksen J

更新日期：1997-12-01 00:00:00

abstract：:Our previous studies in the Sprague-Dawley rat showed that the intrinsic antinociceptive effects of oxycodone are naloxone reversible in a manner analogous to morphine but that in contrast to morphine, oxycodone's antinociceptive effects have a rapid onset of maximum effect (approximately 5-7 min compared to 30-45 min...

journal_title：Pain

authors： Ross FB,Smith MT

更新日期：1997-11-01 00:00:00

abstract：:Acute zoster infection may be followed by a chronic pain syndrome, i.e., postherpetic neuralgia (PHN). Besides older age, the intensity of pain and neuronal damage within the acutely affected body region are regarded as predictors or risk factors for PHN. As an alternative approach an underlying peripheral polyneuropa...

journal_title：Pain

authors： Baron R,Haendler G,Schulte H

更新日期：1997-11-01 00:00:00

abstract：:Neuropathic pain may be effectively relieved by electric stimulation of the spinal cord (SCS). However, the underlying mechanisms for the ensuing pain relief are poorly understood. In a rat model of neuropathy displaying hypersensitivity to innocuous tactile stimuli, (allodynia), we have earlier demonstrated that SCS ...

journal_title：Pain

authors： Cui JG,O'Connor WT,Ungerstedt U,Linderoth B,Meyerson BA

更新日期：1997-10-01 00:00:00

abstract：:The blockade of spinal glycine receptors with intrathecal (i.t.) strychnine produces segmentally-localized allodynia in the rat; a reversible and highly reproducible effect that is attained without peripheral or central nerve injury. We investigated the effect of i.v. mexiletine, an orally active congener of lidocaine...

journal_title：Pain

authors： Khandwala H,Hodge E,Loomis CW

更新日期：1997-09-01 00:00:00

abstract：:The significance of preamputation pain for the development of postamputation stump and phantom pain has been discussed over the years and is still a matter of dispute. It has been argued that preamputation pain increases the risk of phantom pain and that phantom pain is a revivification of pain experienced before the ...

journal_title：Pain

authors： Nikolajsen L,Ilkjaer S,Krøner K,Christensen JH,Jensen TS

更新日期：1997-09-01 00:00:00

abstract：:Morphine (M) and hydromorphone (HM) are commonly used opioid analgesics for cancer pain. Opioid rotation is often necessary in the event of toxicity and/or inadequate analgesia. Equianalgesic reference tables based on single dose comparisons are possibly inadequate for patients on chronic treatment and developing tole...

journal_title：Pain

authors： Lawlor P,Turner K,Hanson J,Bruera E

更新日期：1997-08-01 00:00:00

abstract：:Age-related changes in the facial expression of pain during the first 18 months of life have important implications for our understanding of pain and pain assessment. We examined facial reactions video recorded during routine immunization injections in 75 infants stratified into 2-, 4-, 6-, 12-, and 18-month age group...

journal_title：Pain

authors： Lilley CM,Craig KD,Grunau RE

更新日期：1997-08-01 00:00:00

abstract：:The endogenous opioid peptide dynorphin A has non-opioid effects that can damage the spinal cord when given in high doses. Dynorphin has been shown to increase the receptive field size of spinal cord neurons and facilitate C-fiber-evoked reflexes. Furthermore, endogenous dynorphin levels increase following damage to t...

journal_title：Pain

authors： Laughlin TM,Vanderah TW,Lashbrook J,Nichols ML,Ossipov M,Porreca F,Wilcox GL

更新日期：1997-08-01 00:00:00

abstract：:Substance P (SP) is released from primary afferent fibers in response to nociceptive stimuli. Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers. Capsaicin pretreatment decreases the content and release of SP from p...

journal_title：Pain

authors： Goettl VM,Larson DL,Portoghese PS,Larson AA

更新日期：1997-07-01 00:00:00

abstract：:Pain symptoms of many disorders are reported to vary with menstrual stage. This study investigated how pain thresholds to electrical stimulation of the skin, subcutis and muscle tissue varied with menstrual stage in normal women and compared these variations with those in women with dysmenorrhea and in healthy men at ...

journal_title：Pain

authors： Giamberardino MA,Berkley KJ,Iezzi S,de Bigontina P,Vecchiet L

更新日期：1997-06-01 00:00:00

abstract：:Activation of supraspinal gamma-aminobutyric acid-A (GABAA) receptors is known to result in antagonism of opioid analgesia. Since benzodiazepines enhance the action of GABA at GABAA receptors, we hypothesized that administration of these agents for preoperative sedation might antagonize the analgesic effects of opioid...

journal_title：Pain

authors： Gear RW,Miaskowski C,Heller PH,Paul SM,Gordon NC,Levine JD

更新日期：1997-05-01 00:00:00

abstract：:The analgesic effect of systemic ibuprofen was investigated with two human experimental pain models: (i) static mechanical stimulation of the inter digital web between the 2nd and 3rd finger and (ii) primary and secondary hyperalgesia induced by a 7-min burn injury on the calf. In each double-blind, randomized, two-wa...

journal_title：Pain

authors： Petersen KL,Brennum J,Dahl JB

更新日期：1997-04-01 00:00:00

abstract：:The physiological properties of joint capsule mechanoreceptors in the ankle joint of the chicken were studied in the 3-h period immediately after intra-articular injection of microcrystal sodium urate. The electrical activity was recorded from single C- and A-delta sensory fibres dissected from the parafibular nerve. ...

journal_title：Pain

authors： Gentle MJ

更新日期：1997-04-01 00:00:00

abstract：:This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root inj...

journal_title：Pain

authors： Mailis A,Plapler P,Ashby P,Shoichet R,Roe S

更新日期：1997-03-01 00:00:00

abstract：:Substance P like immunoreactivity (SPLI) and total protein (TP) concentrations in plasma and saliva were measured in 80 healthy female patients divided into the following four groups: women in group 1 were not pregnant and they were awaiting tubal ligation; women in group 2 were not pregnant but they experienced acute...

journal_title：Pain

authors： Dalby PL,Ramanathan S,Rudy TE,Roy L,Amenta JS,Aber A

更新日期：1997-02-01 00:00:00

abstract：:Data from daily diaries were used to analyze pain coping processes in rheumatoid arthritis patients. For 30 consecutive days, 53 individuals described the pain coping strategies they used that day and rated the efficacy of their coping, joint pain, and positive and negative mood. Relations among variables were examine...

journal_title：Pain

authors： Keefe FJ,Affleck G,Lefebvre JC,Starr K,Caldwell DS,Tennen H

更新日期：1997-01-01 00:00:00

abstract：:The aim of the present study was to test (1) whether muscle pain is influenced by temporal and spatial summation, and (2) whether sequential noxious muscle stimuli applied at hourly interstimulus-intervals could produce an increased sensation of pain due to central hyperexcitability. In the study eleven healthy men we...

journal_title：Pain

authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

更新日期：1997-01-01 00:00:00

abstract：:This open prospective study evaluated the combination of initial dose titration with patient-controlled analgesia (PCA) and long-term treatment with transdermal fentanyl in 50 cancer patients requiring opioids for severe pain. The delivery rate of the first transdermal therapeutic system (TTS) was calculated from the ...

journal_title：Pain

authors： Grond S,Zech D,Lehmann KA,Radbruch L,Breitenbach H,Hertel D

更新日期：1997-01-01 00:00:00

abstract：:We assessed nimodipine's ability to increase the analgesic effect of morphine in 32 patients suffering from cancer pain in a double-blind, placebo controlled cross-over study. Morphine administration began a few days before the start of the study. The analgesic effects of two combinations were compared: morphine (M) p...

journal_title：Pain

authors： Roca G,Aguilar JL,Gomar C,Mazo V,Costa J,Vidal F

更新日期：1996-12-01 00:00:00